Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Amikacin and Antioxidants

supplement:

Antioxidants

Research Papers that Mention the Interaction

Modulation of melanogenesis and the antioxidant status of melanocytes resulting from the use of amikacin in vitro may explain a potential role of melanin and melanocytes in the mechanisms of aminoglycosides ototoxic effects in vivo.
Toxicology in vitro : an international journal published in association with BIBRA  •  2013  |  View Paper
Our findings showed that the activities of the antioxidant enzymes such as superoxide dismutase (p<0.001, 62.2%), catalase (p<0.05, 47.5%) were significantly lowered along with increase in the MDA levels (66.0%) after the single treatment of amikacin as compared to control group.
Current clinical pharmacology  •  2008  |  View Paper
All antioxidant enzymes had significantly lower activity in the amikacin group (p < or = 0.05) than in the control group.
Journal of the American Academy of Audiology  •  2003  |  View Paper