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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Amikacin and Antioxidants



Research Papers that Mention the Interaction

Modulation of melanogenesis and the antioxidant status of melanocytes resulting from the use of amikacin in vitro may explain a potential role of melanin and melanocytes in the mechanisms of aminoglycosides ototoxic effects in vivo.
Toxicology in vitro : an international journal published in association with BIBRA  •  2013  |  View Paper
Our findings showed that the activities of the antioxidant enzymes such as superoxide dismutase (p<0.001, 62.2%), catalase (p<0.05, 47.5%) were significantly lowered along with increase in the MDA levels (66.0%) after the single treatment of amikacin as compared to control group.
Current clinical pharmacology  •  2008  |  View Paper
All antioxidant enzymes had significantly lower activity in the amikacin group (p < or = 0.05) than in the control group.
Journal of the American Academy of Audiology  •  2003  |  View Paper