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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Amantadine and Quinine



Research Papers that Mention the Interaction

Renal clearance of amantadine (13.2 ± 5.8 L/hr) was significantly inhibited by quinine (9.7 ± 4.8 L/hr) and quinidine (8.9 ± 4.0 L/hr) only in male subjects and was not associated with age.
Clinical pharmacology and therapeutics  •  1993  |  View Paper
Lastly, the renal excretion of amantadine was inhibited significantly by quinidine and quinine in men but not in women.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine  •  1994  |  View Paper
Amantadine accumulation was inhibited competitively by quinine and quinidine with Ki values of 32 +/- 3 and 84 +/- 11 microM, respectively (n = 4).
Quinine and quinidine again inhibited amantadine accumulation competitively by the slices, with Ki values of 368 +/- 28 and 780 +/- 84 microM, respectively (n = 4).
The Journal of pharmacology and experimental therapeutics  •  1990  |  View Paper