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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Amantadine
supplement:
Quinidine
Research Papers that Mention the Interaction
“Renal clearance of amantadine (13.2 ± 5.8 L/hr) was significantly inhibited by quinine (9.7 ± 4.8 L/hr) and quinidine (8.9 ± 4.0 L/hr) only in male subjects and was not associated with age.”
Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine“Lastly, the renal excretion of amantadine was inhibited significantly by quinidine and quinine in men but not in women.”
“ Amantadine accumulation was inhibited competitively by quinine and quinidine with Ki values of 32 +/- 3 and 84 +/- 11 microM, respectively (n = 4).”
“Quinine and quinidine again inhibited amantadine accumulation competitively by the slices, with Ki values of 368 +/- 28 and 780 +/- 84 microM, respectively (n = 4).”
Stereoselective inhibition of amantadine accumulation by quinine and quinidine in rat renal proximal tubules and cortical slices.
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