Possible Interaction: Amantadine and Dextroamphetamine

“Also, the prior administration of D145 or amantadine inhibited the development of the biting components of apomorphine and d-amphetamine stereotypy.”

“However, when administered concurrently with either apomorphine or d-amphetamine amantadine antagonised the stereotyped behaviour.”

“this effect was less marked if amantadine was injected 1 h before (+)-amphetamine and non-existent if the interval was 2 h. Considering the important therapeutic effect of amantadine on akinesia and rigidity, we examined the effect of this drug on the prochlorpemazine-induced catalepsy in rats.”

“Low concentrations of amantadine , tetracaine, and tetrodotoxin increased the facilitatory response to (+)-amphetamine while the inhibitory effects of (+)-amphetamine were potentiated by higher concentrations of these antagonists; similar biphasic effects were observed with (-)-amphetamine and tetracaine.”

“ 1-Adamantanamine (amantadine) pretreatment significantly reduced the motor hyperactivity and hyperthermia caused by d-amphetamine in reserpinized mice.”

“In drug-naive mice, when amantadine was administered after d-amphetamine , the motor activity caused by the latter also was decreased.”

“The stimulant effects of amantadine and d-amphetamine summated but did not interact, response rates after d-amphetamine being augmented by pretreatment with amantadine except at intervals at which amantadine was by itself depressant.”

“Abstract Amantadine hydrochloride , unexpectedly, was found to block certain effects of d-amphetamine sulfate.”