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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Aluminum Hydroxide and Citric Acid

Research Papers that Mention the Interaction

Although no evidence of maternal and embryo/fetal toxicity was observed when high doses of aluminum hydroxide were given orally to pregnant rats and mice during organogenesis, signs of maternal and developmental toxicity were found in mice when aluminum hydroxide was given concurrently with citric or lactic acids.
Neurotoxicology and teratology  •  1995  |  View Paper
Citric acid did not significantly affect the antacid-induced PGE2 release except in combination with a low dose of aluminium hydroxide , with which a significant increase was seen.
Scandinavian journal of gastroenterology  •  1987  |  View Paper
In terms of CA, a more striking negative effect on the growth ability of the flocs was observed compared to P. The strong complexing/coordination interactions between CA and aluminum hydroxide is the main reason behind the influence.
Journal of environmental sciences  •  2021  |  View Paper
Citric acid has been shown to act as an agent for increasing the solubility of aluminum oxyhydroxides in aqueous solutions of high (>2.47 mol/mol) hydroxide-to-aluminum ratios.
Langmuir : the ACS journal of surfaces and colloids  •  2005  |  View Paper