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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Aluminum Hydroxide and Calcium Citrate

Research Papers that Mention the Interaction

On 3 consecutive days, urinary aluminum excretion levels were 11.1 +/- 3.23, 8.8 +/- 2.9, and 5.3 +/- 0.7 times greater during the administration of calcium citrate with aluminum hydroxide than with aluminum hydroxide alone.
These values increased during aluminum hydroxide therapy, but values were much greater when calcium citrate was ingested with aluminum hydroxide.
Thus, calcium citrate markedly enhances the absorption of aluminum from aluminum hydroxide and the two must not be prescribed together in patients with renal failure.
American journal of kidney diseases : the official journal of the National Kidney Foundation  •  1991  |  View Paper