Possible Interaction: Alprostadil and Vitamin E

“Platelet function was significantly decreased by vitamin E as revealed by the decreased platelet aggregation in response to ADP and arachidonic acid, the increased sensitivity to inhibition by PGE1 , the decreased plasma beta-thromboglobulin concentration and the decreased ATP secretion.”

“At a subthreshold concentration 200 and 2 microM, respectively, both alpha-tocopherol and quercetin essentially increased the antiplatelet effects of PGI2, PGE1 and iloprost.”

“Patients with cystic fibrosis who had deficient vitamin E levels (plasma alpha-tocopherol, less than 500 micrograms/… response to prostaglandin E1 compared with patients who had sufficient vitamin E, and supplementation with water-miscible vitamin E in these patients resulted in significant …) and in cAMP response to prostaglandin E1 (…).”

“Plasma alpha-tocopherol levels correlated significantly with platelet cAMP response to prostaglandin E1 in patients with cystic fibrosis (r = 0.58, p less than 0.05).”

“Adriamycin, PGE1 , R020-1724, papaverine, mutamycin, and cis-platinum increased the expression of morphological differentiation of NB cells, but vitamin E enhanced the effect of these agents for this criterion.”

“ Vitamin E in combination with 5-FU, adriamycin, R020-1724, vincristine, sodium butyrate, chlorozotocin, or PGE1 produced a synergistic effect on growth inhibition of NB cells, whereas, vitamin E in combination with bleomycin, CCNU, DTIC, mutamycin, or cis-platinum produced an additive effect for the same criterion.”