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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alprostadil
supplement:
Vitamin C
Research Papers that Mention the Interaction
“In the presence of ascorbic acid an increased formation of PGF1 alpha, PGE1 and PGE2 was observed in platelets.”
Ascorbic acid enhances the formation of prostaglandin E1 in washed human platelets and prostacyclin in rat aortic rings.“ Vitamin C stimulates the formation of PGE1 in human platelets.”
“ PGE1 biosynthesis may be affected by nutritional factors including essential fatty acids, pyridoxine, vitamin C , and zinc.”
“Alcohol, vitamin C and chloroquine selectively enhance DGLA conversion to PGE1 : opiates may either enhance of inhibit PGE1 formation selectively depending on receptor type.”
“Treatment of the cells with 100 μg/ml ascorbic acid potentiated the response of cAMP to both PTH and PGE1 , while cell growth was inhibited.”
Effects of ascorbic acid on alkaline phosphatase activity and hormone responsiveness in the osteoblastic osteosarcoma cell line UMR-106“Addition of ascorbic acid , prostaglandin E1 and both essential fatty acids was found to reduce BL6 growth while PGE1 and to a lesser extent the essential fatty acids reduced LLCMK cell growth.”
“A possible role of PGE1 in reducing platelet activity in the presence and absence of vitamin C is discussed.”
“ PGE1 , E2, or F2α produced a highly significant decrease in the ovarian content of ascorbic acid in intact and hypophysectomized immature rats with luteinized ovaries due to previous treatment with pregnant mares′ serum (PMS) and human chorionic gonadotropin (hCG).”
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