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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alprostadil
supplement:
Selenium
Research Papers that Mention the Interaction
“There are studies suggesting that selenium supplementation decreases the cyclooxygenase-2 (COX-2) protein and PGE-2 levels in cancer cells and increases the efficacy of cetuximab in patients with advanced CRC [6 /8].”
Low selenium levels in serum and increased concentration in neoplastic tissues in patients with colorectal cancer: Correlation with serum carcinoembryonic antigen“Adding PGE1 to confluent cells maintained in its absence caused 71 +/- 17% (mean +/- SE , 10 experiments) inhibition of the conversion of retinol into retinoic acid.”
Prostaglandin E and 12-O-tetradecanoylphorbol-13-acetate are negative modulators of retinoic acid synthesis.“Intraperitoneal injection of prostaglandin E1 (PGE) produces a transient hypothermia in rats that lasts 1-2 h. Rats exposed to an … temperature (Ta) of 26 degrees C displayed a decrease in rectal temperature (Tre) of 0.95 +/- 0.12 degrees C SE ) after … with PGE (100 micrograms/kg ip).”
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