Possible Interaction: Alprostadil and Glucose

“Insulin responses to glucose during PGE1 infusion (0.2 microgram/Kg/min) were significantly lower than in control infusions (p less than 0.001 at 2, 5, 10 and 15 min).”

“Only PGE1 was able to increase significantly (p less than 0.05) 14CO2 production from labelled glucose in uterine strips from OVED rats.”

“At the fetal side (singly-perfused placenta) cytochalasin B (50 microM), ethylidene-D-glucose (100 mM) and PGE1 (1 microM) partially inhibited D-glucose uptake whereas cortisol (50 microM) and progesterone (100 microM) had no effect.”

“In contrast, prostaglandin E1 (1 microM) markedly reduced the Km and Vmax for D-glucose at both interfaces and the inhibitory effect was reflected in a reduction in specific transplacental D-glucose transfer.”

“During 5-h culture in the presence of radioactive glucose, PGE-2 (10 micrograms/ml) significantly inhibited incorporation of glucose into the acid-soluble glycogen pool.”

“ PGE-2 at 1 and 10 micrograms/ml and PGF-2 alpha at 1 microgram but not 10 micrograms/ml stimulated incorporation of glucose into non-glycogen macromolecules during culture.”

“The results indicate that PGE-2 and PGF-2 alpha, in physiological concentrations, directly influence the metabolism of glucose by preimplantation embryos.”

“The treatment with PGE1 produces an inhibitory effect on the insulinic response to glucose , as well as hyperglycemia and hyperglucagonemia.”

“In the presence of 4.4 mM glucose, PGE1 produced a significant augmentation in somatostatin release, but not in insulin release, compared to the effect of glucose alone.”

“ PGE1 also augmented somatostatin and insulin secretion induced by 16.7 mM glucose.”

“ PGE1 infusion significantly increased glucose and glucagon levels, while PGA1 had no effect.”

“ Prostaglandin E1 (0.95 × 10−6m) significantly increased glucose-1 -14C oxidation in dog thyroid slices but had no effect on 32P incorporation into phospholipid.”

“Insulin and prostaglandin E1 inhibited the lipolytic action of theophylline on white fat cells and stimulated the metabolism of glucose by cells isolated and incubated in K+- free buffer.”