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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alprostadil
supplement:
Gamma-Linolenic Acid
Research Papers that Mention the Interaction
“ GLA inhibits inflammatory responses by regulating nuclear factor-kappa B and activator protein-1 activation and prostaglandin E1.”
Oral evening primrose oil as an adjuvant treatment option in chronic lichenoid dermatitis“Most of the agents used (aspirin, imidazole, lithium carbonate and ascorbic acid) produced results consistent with the idea that elevation of levels of thromboxane A2 (TxA2) and/or PGE1 may be important as regards the actions of GLA.”
“In conclusion, dietary GLA enhances mouse macrophage-derived prostaglandin E1 , which inhibits vascular SMC proliferation.”
Dietary gamma-linolenic acid enhances mouse macrophage-derived prostaglandin E1 which inhibits vascular smooth muscle cell proliferation.“The dietary administration of GLA increased the in vitro production by the aorta of prostaglandin E1 derived from dihomo-GLA, but did not significantly influence the production of prostaglandin E2 derived from AA by the aorta and the thromboxane B2 level in serum.”
“However, prostaglandin E1 , which is formed from GLA in vivo, showed partial reversal of tumor-induced lipolysis and probably accounted for the anticachectic effect of GLA.”
“The challenge with 10(-7) M GLA (delivered immediately after isolation) enhanced significantly the output of PGE1 but did not influence the generation and release of PGE2 or PGF2 alpha.”
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