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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Alprostadil and Gamma-Linolenic Acid

Research Papers that Mention the Interaction

GLA inhibits inflammatory responses by regulating nuclear factor-kappa B and activator protein-1 activation and prostaglandin E1.
Dermatologic therapy  •  2021  |  View Paper
Most of the agents used (aspirin, imidazole, lithium carbonate and ascorbic acid) produced results consistent with the idea that elevation of levels of thromboxane A2 (TxA2) and/or PGE1 may be important as regards the actions of GLA.
Prostaglandins, leukotrienes, and medicine  •  1985  |  View Paper
In conclusion, dietary GLA enhances mouse macrophage-derived prostaglandin E1 , which inhibits vascular SMC proliferation.
The Journal of nutrition  •  1997  |  View Paper
The dietary administration of GLA increased the in vitro production by the aorta of prostaglandin E1 derived from dihomo-GLA, but did not significantly influence the production of prostaglandin E2 derived from AA by the aorta and the thromboxane B2 level in serum.
Annals of nutrition & metabolism  •  1996  |  View Paper
However, prostaglandin E1 , which is formed from GLA in vivo, showed partial reversal of tumor-induced lipolysis and probably accounted for the anticachectic effect of GLA.
Cancer research  •  1991  |  View Paper
The challenge with 10(-7) M GLA (delivered immediately after isolation) enhanced significantly the output of PGE1 but did not influence the generation and release of PGE2 or PGF2 alpha.
Prostaglandins  •  1988  |  View Paper