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“ Prostaglandin E1 , which stimulates adenylate cyclase to form cAMP, inhibited the antibody effects 50% at 50-fold the concentration required for equivalent inhibition of aggregation and release by epinephrine.”
“Ca(2+)-mobilizing effects of lipoproteins were potentiated about 4-fold by epinephrine and completely blocked by prostaglandin E1 both in platelets of healthy and HFH subjects.”
“We found that: (i) ticlopidine inhibits aggregation by ADP but … by Adr of ADP-induced aggregation; (ii) ADP, Adr or thrombin … raised by PGE1 , an effect inhibited by ticlopidine only for ADP and not for Adr or … (iii) Ca2+ influx and Ca2+ mobilization from internal stores were not affected.”
“In intact platelets, PMA, like PGE1, stimulated the return of the calcium transient to resting values after a thrombin stimulus, but only the PGE1 effect was reversed by adrenaline.”
“Pretreatment of the PRP with epinephrine increased the maximum transmittance during ADP aggregation, produced less-reversible aggregates (less subject to deaggregation by PGE1 ), and increased the aggregate flow resistance over the range of filtration pressures tested.”
“The inhibition of ADP-induced aggregation and rise in [Ca2+]i is potentiated by PGE1 which stimulates adenylate cyclase and is inhibited by adrenaline which inhibits adenylate cyclase.”
“ Adrenaline , high thrombin concentrations and, in the absence of phosphocreatine and creatine kinase, ADP inhibited cyclic [3H]AMP formation induced by PGE1.”
“Coupling to adenylate cyclase was also assessed in separate studies of the inhibition by adrenaline of PGE1 stimulated cyclic AMP accumulation in whole platelets.”