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Last Updated: 2 years ago

Possible Interaction: Alprostadil and Epinephrine



Research Papers that Mention the Interaction

Prostaglandin E1 , which stimulates adenylate cyclase to form cAMP, inhibited the antibody effects 50% at 50-fold the concentration required for equivalent inhibition of aggregation and release by epinephrine.
Blood  •  1977  |  View Paper
PGE1 potentiates contractions caused by other agents such as epinephrine.
Fertility and sterility  •  1977  |  View Paper
Prostaglandin E1 treatment weakened SC reduction in response to ADP and epinephrine (SC of 8.8 ± 1.8% and 9.5 ± 2.0%, respectively).
Platelets  •  2008  |  View Paper
Ca(2+)-mobilizing effects of lipoproteins were potentiated about 4-fold by epinephrine and completely blocked by prostaglandin E1 both in platelets of healthy and HFH subjects.
Atherosclerosis  •  1992  |  View Paper
We found that: (i) ticlopidine inhibits aggregation by ADP but … by Adr of ADP-induced aggregation; (ii) ADP, Adr or thrombin … raised by PGE1 , an effect inhibited by ticlopidine only for ADP and not for Adr or … (iii) Ca2+ influx and Ca2+ mobilization from internal stores were not affected.
Biochemical pharmacology  •  1990  |  View Paper
In intact platelets, PMA, like PGE1, stimulated the return of the calcium transient to resting values after a thrombin stimulus, but only the PGE1 effect was reversed by adrenaline.
The Biochemical journal  •  1988  |  View Paper
Pretreatment of the PRP with epinephrine increased the maximum transmittance during ADP aggregation, produced less-reversible aggregates (less subject to deaggregation by PGE1 ), and increased the aggregate flow resistance over the range of filtration pressures tested.
Thrombosis research  •  1987  |  View Paper
The inhibition of ADP-induced aggregation and rise in [Ca2+]i is potentiated by PGE1 which stimulates adenylate cyclase and is inhibited by adrenaline which inhibits adenylate cyclase.
Thrombosis research  •  1987  |  View Paper
Adrenaline , high thrombin concentrations and, in the absence of phosphocreatine and creatine kinase, ADP inhibited cyclic [3H]AMP formation induced by PGE1.
The Biochemical journal  •  1987  |  View Paper
Coupling to adenylate cyclase was also assessed in separate studies of the inhibition by adrenaline of PGE1 stimulated cyclic AMP accumulation in whole platelets.
European journal of pharmacology  •  1985  |  View Paper
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