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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Alprostadil
supplement:
Eicosatrienoic Acid
Research Papers that Mention the Interaction
“Incubation of washed platelets (1 x 10(8)/ml) with 125 microM DHLA increased intraplatelet levels of PGE1 from 197 +/- 7 to 1622 +/- 9.7 picograms/10(8), cAMP from 3 +/- 0.8 to 31 +/- 1.9 picomoles/10(8), and inhibited collagen-induced PAg.”
Effect of in vitro incorporation of prostanoid precursors, superoxide radical and hydrogen peroxide on platelet function.“Synovial cells incorporated the DGLA, and rIL-… beta-stimulated cells that were incubated with DGLA exhibited a 14-… increase in PGE1 (to 25.2 +/- 6.0 ng/ml, mean +/- SD) and a 70% decrease in PGE2 (to 25.2 +/- 4.2 ng/ml) compared with cells in control medium.”
“b. There are regulatory interactions between the 1 and 2 series: PGE1 inhibits AA mobilisation while TXA2 and PGE2 stimulate dihomogammalinolenic acid (DGLA) mobilisation and its conversion to PGE1.”
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