Possible Interaction: Alprostadil and Carrageenan

“This effect of PGE1 , was maximal when it was injected together with carrageenan , there being a reduction in the action of PGE1 if carrageenan injection was delayed after PGE1 injection.”

“Placement of PGE1 into subcutaneous air blebs at the time of carrageenan injection retarded movement of polymorphonuclear leukocytes into the focus of inflammation and produced a concentration-dependent reduction in exudate β-glucuronidase and lactate dehydrogenase activities, an effect also observed in adrenalectomized rats.”