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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alprostadil and Calcium Supplement

Research Papers that Mention the Interaction

STA2 and U46619, TXA2/PGH2 agonists, PGE2/PGE1 , iloprost/PGI2, and thrombin elevated the intracellular concentrations of Ca2+ ([Ca2+]i) , as determined by Fura-2 fluorescence signals.
Blood  •  1991  |  View Paper
This enzymatic activity is strongly stimulated by NaF and 5'-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.
Biochimica et biophysica acta  •  1976  |  View Paper
Co‐incubation with prostaglandins E1 and E2 (PGE1, PGE2) (10 μM) but not prostaglandin F2α (PGF2α) (10 μM) significantly inhibited calcium‐ , GTP‐γ‐S and mastoparan‐evoked secretion by 30 – 50%.
PGE2 was much more potent than PGE1 and significantly inhibited GTP‐γ‐S‐ and calcium‐evoked … 10 nM and above and mastoparan‐evoked secretion above 1 μM. The inhibitory effects of PGE1 and … calcium‐ , GTP‐γ‐S‐ and mastoparan‐stimulated ACTH secretion … permeabilized cells were pertussis toxin (PTX) sensitive.
British journal of pharmacology  •  2002  |  View Paper
PGE1 increased intra‐cellular levels of total inositol phosphates (IP), cyclic GMP, cyclic AMP, and calcium ([Ca2+]i).
Journal of neurochemistry  •  1991  |  View Paper
Exogenously administered PGE1 or PGE2, like atropine, markedly decreased both the flow and calcium concentration of parasympathetically evoked rat parotid saliva; PGF2 alpha was less effective.
Prostaglandins  •  1986  |  View Paper
The results suggest that PGE1 reduces Ca conductance and that this action may underlie its inhibitory action on transmitter release at adrenergic and cholinergic nerve terminals.
Brain Research  •  1985  |  View Paper
Instead, PGE1 increases mobilization of Ca++ from the same high affinity La+++-resistant sites affected by Ang III and NE and, in this manner, may increase responses to these two stimulatory agents.
Prostaglandins  •  1980  |  View Paper
From these results it is suggested that (1) in the … must be more dominant than beta-receptors; (2) PGE1 will produce a depolarization of … increase an active transport of calcium ions into smooth muscle cells; and (3) the relaxant responses … an increase in cellular cyclic adenosine monophosphate (AMP) contents.
Urology  •  1979  |  View Paper
The action of PGE1 was counteracted by decreasing and potentiated by increasing the extracellular calcium concentration.
Acta physiologica Academiae Scientiarum Hungaricae  •  1979  |  View Paper
We have investigated the effects of PGE1 in smooth muscle and have demonstrated that while some PGE1 is required for both calcium release and calcium removal , high levels of PGE1 block both processes.
Annals of the New York Academy of Sciences  •  1979  |  View Paper
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