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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alprostadil
supplement:
Arachidonic Acid
Research Papers that Mention the Interaction
“ Arachidonic acid-induced platelet aggregation was inhibited by prostaglandins E1 and F2α (PGE1 and PGF2α), papaverine and dibutyryl cyclic AMP.”
Substances that increase the cyclic AMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid“Derivatives of alpha-linolenic acid 15-HETE and prostaglandin E1 (PGE1) have weak pro-inflammatory action, or even anti-inflammatory (PGE1), and additionally, they inhibit the transformation of arachidonic acid (AA) to leukotriens.”
“ Prostaglandin E1 , prostacyclin, carbacyclin, forskolin or dibutyryl cAMP prevented platelet activation by and desensitization to AA and to U46619 under conditions where the formation of thromboxane B2 was not significantly modified.”
“Since PGE1 blocks mobilisation of arachidonic acid , a lack of PGE1 is likely to be associated with arachidonate mobilisation and an excess of 2 series PGs.”
“Furthermore, dBcAMP and PGE1 both inhibit platelet aggregation induced by either arachidonic acid or prostaglandin H2 without affecting the production of prostaglandin metabolites from these compounds.”
“ PGE1 at 1 microM caused a sharp increase in cAMP and complete inhibition of platelet aggregation induced by AA plus EPI.”
The lack of correlation between inhibition of aggregation and cAMP levels with canine platelets.“Between 1 and 100 ng/ml PGE1 and PGE2 inhibited arachidonic acid- and 5HT-induced aggregation dose-dependently.”
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