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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alprostadil and Arachidonic Acid

Research Papers that Mention the Interaction

Arachidonic acid-induced platelet aggregation was inhibited by prostaglandins E1 and F2α (PGE1 and PGF2α), papaverine and dibutyryl cyclic AMP.
Agents and Actions  •  2005  |  View Paper
Derivatives of alpha-linolenic acid 15-HETE and prostaglandin E1 (PGE1) have weak pro-inflammatory action, or even anti-inflammatory (PGE1), and additionally, they inhibit the transformation of arachidonic acid (AA) to leukotriens.
Przeglad lekarski  •  2007  |  View Paper
Prostaglandin E1 , prostacyclin, carbacyclin, forskolin or dibutyryl cAMP prevented platelet activation by and desensitization to AA and to U46619 under conditions where the formation of thromboxane B2 was not significantly modified.
European journal of pharmacology  •  1986  |  View Paper
Since PGE1 blocks mobilisation of arachidonic acid , a lack of PGE1 is likely to be associated with arachidonate mobilisation and an excess of 2 series PGs.
Medical hypotheses  •  1981  |  View Paper
Furthermore, dBcAMP and PGE1 both inhibit platelet aggregation induced by either arachidonic acid or prostaglandin H2 without affecting the production of prostaglandin metabolites from these compounds.
The Journal of clinical investigation  •  1977  |  View Paper
PGE1 at 1 microM caused a sharp increase in cAMP and complete inhibition of platelet aggregation induced by AA plus EPI.
Thrombosis research  •  1982  |  View Paper
Between 1 and 100 ng/ml PGE1 and PGE2 inhibited arachidonic acid- and 5HT-induced aggregation dose-dependently.
Prostaglandins  •  1981  |  View Paper