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Last Updated: 3 years ago

Possible Interaction: Alprazolam and Yohimbine



Research Papers that Mention the Interaction

Concomitant yohimbine administration antagonized the effects of alprazolam on blood pressure and attenuated alprazolam-induced changes in cortisol and subjective ratings.
Psychopharmacology  •  2004  |  View Paper
Long-term alprazolam treatment significantly reduced plasma MHPG baseline and blunted the yohimbine-induced increases in plasma MHPG, anxiety-nervousness, and sitting systolic blood pressure.
Archives of general psychiatry  •  1985  |  View Paper
In view of previous results indicating that the panic-promoting drug yohimbine increases flight/escape reactions and that the panicolytic compound alprazolam reduces these responses, we tentatively suggest that the preferential 5-HT2A receptor antagonist pirenperone may have some efficacy in improving panic attacks.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper
In a dose (0.5 mg/kg) which did not alter the behavior by itself, the alpha 2-adrenoceptor antagonist yohimbine consistently was found to enhance the anticonflict effect of APZ (0.5 mg/kg).
Journal of neural transmission. General section  •  1990  |  View Paper
This effect of alprazolam was effectively antagonized by either of the two selective alpha 2-receptor antagonists yohimbine or idazoxane.
Life sciences  •  1986  |  View Paper