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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alprazolam
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“These findings indicate that the inhibitory effect of central gamma-aminobutyric acid-ergic activation by ALP overrides the stimulatory effect of the MET-induced lack of negative F feedback on corticotroph secretion.”
The inhibitory effect of alprazolam, a benzodiazepine, overrides the stimulatory effect of metyrapone-induced lack of negative cortisol feedback on corticotroph secretion in humans.“ Alprazolam also augmented the ability of suboptimal doses of GABA to inhibit antigen-specific T cell responses in vitro.”
“Benzodiazepines, such as Valium and Xanax ®, stimulate GABA receptors, thus mimicking the calming effects of GABA but again do not fix the lack of GABA production.”
“At 0°C, 10 μMγ‐aminobutyric acid GABA ) increased the ability of alprazolam , but not of triazolam, to displace ethyl‐β‐carboline‐3‐carboxylate (β‐CCE) and Ro 15–1788 from these receptors.”
“ GABA enhanced [3H]alprazolam binding while several benzodiazepine receptor ligands were competitive inhibitors of this drug.”
Characterization of [3H]alprazolam binding to central benzodiazepine receptors“ Alprazolam administration produced an increase of GABA levels in cerebellum and striatum and a decrease in the brain stem.”
“ Alprazolam significantly increased GABA levels in the striatum, while nifedipine alone had no effect on neurotransmitter levels and did not modify the ALP effect in this brain region.”
Effect of nifedipine on alprazolam - induced anxiolysis and brain GABA level changes in albino rats.
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