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Last Updated: 3 years ago

Possible Interaction: Alprazolam and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

These findings indicate that the inhibitory effect of central gamma-aminobutyric acid-ergic activation by ALP overrides the stimulatory effect of the MET-induced lack of negative F feedback on corticotroph secretion.
The Journal of clinical endocrinology and metabolism  •  1999  |  View Paper
Alprazolam also augmented the ability of suboptimal doses of GABA to inhibit antigen-specific T cell responses in vitro.
Journal of diabetes research  •  2019  |  View Paper
Benzodiazepines, such as Valium and Xanax ®, stimulate GABA receptors, thus mimicking the calming effects of GABA but again do not fix the lack of GABA production.
Medical science monitor : international medical journal of experimental and clinical research  •  2012  |  View Paper
At 0°C, 10 μMγ‐aminobutyric acid GABA ) increased the ability of alprazolam , but not of triazolam, to displace ethyl‐β‐carboline‐3‐carboxylate (β‐CCE) and Ro 15–1788 from these receptors.
Journal of neurochemistry  •  1985  |  View Paper
GABA enhanced [3H]alprazolam binding while several benzodiazepine receptor ligands were competitive inhibitors of this drug.
Pharmacology Biochemistry and Behavior  •  1990  |  View Paper
Alprazolam administration produced an increase of GABA levels in cerebellum and striatum and a decrease in the brain stem.
Alprazolam significantly increased GABA levels in the striatum, while nifedipine alone had no effect on neurotransmitter levels and did not modify the ALP effect in this brain region.
Neurosciences  •  2003  |  View Paper