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Last Updated: 2 years ago

Possible Interaction: Alprazolam and Caffeine

supplement:

Caffeine

Research Papers that Mention the Interaction

Our results indicate that, Alp alone induces apoptosis in human cells but in the presence of caffeine it augments necrosis in a well-regulated pathway.
The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3.
Thus our observations strongly suggest that, alprazolam and caffeine together produce severe cytotoxicity in human cell lines.
Toxicology in vitro : an international journal published in association with BIBRA  •  2009  |  View Paper
Because alprazolam is much shorter-lived (t1/2=32 min) than caffeine (t1/2=3 h) in rats, potency ratios between alprazolam and caffeine changed across session time (from 123 to 4), which determined the expression of the combined effects.
Psychopharmacology  •  2005  |  View Paper
Caffeine and alprazolam antagonized each other's behavioral effects in this study, but did not alter each other's uptake into brain.
Psychopharmacology  •  2005  |  View Paper
Inasmuch as alprazolam was more potent and short-lived than caffeine in decreasing the reinforcement rate (consonant with their respective t(1/2) values, 0.44 and 3.1 hr), the alprazolam/caffeine potency ratio decreased across the session time, which determined the expression of the combined effects.
The Journal of pharmacology and experimental therapeutics  •  1997  |  View Paper