Possible Interaction: Alprazolam and Adrenocorticotropic Hormone

“ Alprazolam reduced ACTH and cortisol while increasing growth hormone.”

“ Alprazolam abolished the CAN-induced increases in ACTH , cortisol, and DHEA levels (1.8 +/- 0.1 pmol/liter, 59.7 +/- 8.6 nmol/liter, and 19.8 +/- 6.7 nmol/liter; P < 0.05), inducing hormonal peaks overlapping with those recorded after placebo in the absence of any treatment.”

“ APZ reduced the mean integrated ACTH and cortisol responses to AVP by 67% and 70% respectively [ACTH, 161.6 +/- 59.7 vs. 53.0 +/- 20.9 pmol/min.”

“This study provides further evidence of the potent inhibitory effects of APZ on ACTH and cortisol release in humans and is the first to find that APZ inhibits AVP-stimulated ACTH and cortisol release.”

“The administration of alprazolam led to a highly significant attenuation of the ACTH increase following the stress interview.”

“Subjects pre-treated with alprazolam showed a strongly blunted response of ACTH as well as total and free cortisol to the TSST.”

“The cortisol peaks after 0.06 μg ACTH were significantly reduced (p<0.02) by AL pre-treatment (115.0±7.7 μg/l) which, in turn, did not modify the cortisol response to the subsequent ACTH bolus (214.7±16.6 μg/l).”

“The gamma-aminobutyric acid (GABA) agonist alprazolam is known to decrease adrenocorticotropic hormone and cortisol concentrations.”

“ APZ caused a smaller percentage reduction in AUC for ACTH in DM compared with controls.”

“The ACTH response to Nal in DM subjects was significantly reduced by APZ.”

“ Alprazolam pretreatment also markedly attenuated the ACTH response to hypoglycemia whereas the cortisol response was only moderately affected.”