Possible Interaction: Alpha-lipoic acid and Vitamin E

“In several studies, the synergism between alpha-lipoic acid and vitamin E has been described and potent antioxidant effects can be obtained when both antioxidants are simultaneously used.”

“This review highlights recent findings showing that the combination of alpha-lipoic acid plus vitamin E effectively reduces oxidative damage in brain and cardiac ischemia as well as in other pathological events related to ROS increasing.”

“Supplementation of vitamin E with and without ALA significantly reduced interleukin-6 concentration.”

“Broilers in VE and combination of ALA and VE group had higher plasma VE concentration than the control and ALA group at 1, 2, and 3 wk of age (P < 0.01).”

“These results suggest that VE and ALA especially when they were combined in the diet had positive effects on mitigating intestinal inflammation and improving nutrient transport beginning at 1 wk of age, which is likely critical in reducing the severity of WB.”

“The combination of ALA and Vit E significantly improved the ATP levels in the liver, heart, kidney and brain and also provided significant improvements the complex I activity in all tissues.”

“ ALA and vitamin E in combination may provide protection against lindane-induced acute toxicity.”

“Compared with the other groups, rats that exercised and received LA had a significantly higher vitamin E concentration in the soleus.”

“ Vitamin E and alpha-lipoic acid are a potent antioxidant combination with the potential to prevent endothelial apoptosis.”

“The antioxidants alpha-lipoic acid and vitamin E have shown synergistic effects against lipid peroxidation by oxidant radicals in several pathological conditions.”

“Presumably, this action is due to a thioctic acid dihydrolipoic acid (TA/DHLA) coupled antioxidant mechanism, which enhances the activity of other antioxidants (i.e. ascorbate, alpha-tocopherol ) by regenerating them from their radical form.”

“ Lipoic acid quenches reactive oxygen species, chelates metal ions, and reduces the oxidized forms of other antioxidants such as vitamin C, vitamin E , and glutathione.”