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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Alpha-lipoic acid and Valsartan

Research Papers that Mention the Interaction

Compared to valsartan alone, valsartan combined with ALA can reduce level of inflammatory cytokines in serum and improve renal function.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP  •  2019  |  View Paper
Conclusions α-lipoic acid combined with valsartan could significantly reduce the level of urinary albumin and oxidative stress, increase antioxidant capacity and alleviate renal function damage in patients with DN, and this will provide a reference for the selection of treatment drugs for DN.
…,α-lipoic acid … valsartan markedly increased the level of SOD ( P = 0.03, SMD = 1.24, 95%CI = 0.32 to 1.03; P = 0.0002, SMD = … = -1.99, 95%CI = -3.02 to − 0.96; P = 0.0001, SMD = -0.69, 95%CI = -1.04 to − 0.34).
α-lipoic acid … valsartan could remarkably reduce UAER ( P < 0.00001, SMD = -1.95, 95%CI = -2.55 to − 1.20; P = 0.03, SMD = -0.85, …, SMD = -0.48, 95%CI = -0.93 to − 0.04) when compared with valsartan or lipoic acid monotherapy in patients with DN.
BMC Endocrine Disorders  •  2021  |  View Paper