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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Valproic Acid
Research Papers that Mention the Interaction
“Based on the pharmacokinetic data, the absolute bioavailability of VA was determined to be 1.3 in the presence of LA.ConclusionsOur study demonstrated for the first time that there is a potential DDI between LA and VA at the mitochondrial β-oxidation level.”
“While further clinical study is essential, our preliminary finding suggested that medical practitioners need to be prudent when managing epileptic patients who are co-administered with both VA and LA.”
Investigation of the Drug–Drug Interaction Between α-Lipoic Acid and Valproate via Mitochondrial β-oxidation“Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2.”
The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study
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