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Last Updated: 2 years ago

Possible Interaction: Alpha-lipoic acid and Tyrosine

supplement:

Tyrosine

Research Papers that Mention the Interaction

A phospho-receptor tyrosine kinase array and cell cycle analysis indicated that α-LA decreased tyrosine phosphorylation levels of EGFR, ErbB2, and Met, and this was associated with an inhibition in the cell-cycle transition from the G1 phase to the S phase without inducing apoptosis.
In the presence of gefitinib and HGF, the addition of α-LA suppressed Met tyrosine phosphorylation, and this was associated with an inhibition in cell growth.
Cancer letters  •  2013  |  View Paper
LA inhibited peroxynitrite-mediated nitration of tyrosine and of a hydrophobic tyrosine analog, N-t-BOC L-tyrosine tert-butyl ester (BTBE), incorporated into liposomes but enhanced tyrosine dimerization.
Free radical biology & medicine  •  2005  |  View Paper
It was suggested that 5-methoxytryptamine, melatonin and alpha-lipoic acid reacted only with the nitrating intermediate of peroxynitrite and inhibited nitration of L-tyrosine.
Chemical & pharmaceutical bulletin  •  2000  |  View Paper
On the other hand, 5-methoxytryptamine and lipoic acid inhibited only the nitration reaction of L-tyrosine , and instead increased the oxidation reaction.
Antioxidants & redox signaling  •  1999  |  View Paper