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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Pilocarpine
Research Papers that Mention the Interaction
“ LA (10, 20 or 30 mg/kg) pretreatment completely blocked pilocarpine‐evoked increases in extracellular glutamate and aspartate concentrations.”
“Therefore, the fact that LA could drastically reduce pilocarpine‐induced increases in glutamate and aspartate should account, at least partly, for its anticonvulsant activity observed in pilocarpine‐induced seizure in rats.”
Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine‐induced seizures“The results of the present study demonstrated that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by reducing oxidative stress in rat hippocampus caused by seizures.”
“In turn, LA plus pilocarpine abolished the appearance of seizures and reversed the decreased in delta-ALA-D and Na(+), K(+)-ATPase activities produced by seizures, when compared to the pilocarpine seizing group.”
“The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by increasing delta-ALA-D and Na(+), K(+)-ATPase activities in rat brain during seizures.”
“The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by increasing AChE and Na+, K+-ATPase activities in rat hippocampus.”
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