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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Paroxetine
Research Papers that Mention the Interaction
“…,paroxetine, … α-lipoic acid can modulate the balance between pro-oxidant and antioxidant processes in the mammalian tissues and these properties of drugs such as indomethacin, meloxicam, … their clinical efficacy and drug-related toxic effects, including gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”
Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress.“In the anxiety models studied, an anxiolytic effect was observed after the administration of LA and PXT.”
“In the tail suspension test, PXT at both doses and in combination with LA caused a significant decrease in immobility time.”
“These data suggest that coadministration of LA and PXT may improve anxiolytic and antidepressant responses, and being more effective than each drug alone.”
Central Effects of Lipoic Acid Associated With Paroxetine in Mice
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