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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
supplement:
Palmitic Acid
Research Papers that Mention the Interaction
“Antioxidant effects of LA ameliorated reactive oxygen species production and endoplasmic reticulum stress and protected against mitochondrial apoptosis in hepatocytes treated with PA.”
“Cotreatment with PA and LA induced an early nuclear translocation of Nrf2 and activated antioxidant enzymes, whereas reduction of Nrf2 by siRNA abolished the benefit of LA on PA-induced lipoapoptosis.”
“Importantly, posttreatment with LA reversed the established damage induced by PA in hepatocytes, as well as preventing obesity-induced oxidative stress and lipoapoptosis in rat liver.”
“Moreover, LA augmented the proliferation capacity of hepatocytes after PA challenge.”
Essential role of Nrf2 in the protective effect of lipoic acid against lipoapoptosis in hepatocytes.“In addition, LA increases the proportion of palmitic , stearic, arachidonic, and DHA in the fatty liver.”
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