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Last Updated: 2 months ago

Possible Interaction: Alpha-lipoic acid and Nitric Oxide

Research Papers that Mention the Interaction

Alpha-lipoic acid significantly increased glutathione level and significantly decreased MDA, NO , TNF-alpha, Fas-L, MMP-2, troponin-I levels, and TGF-beta gene expression.
The review of diabetic studies : RDS  •  2013  |  View Paper
Pre-incubation of cells with alpha-lipoic acid increases their capacity to reduce extracellular ferricyanide, to recycle intracellular dehydroascorbic acid to ascorbate, to decrease reactive oxygen species generated by redox cycling of menadione, and to generate nitric oxide.
Free radical biology & medicine  •  2002  |  View Paper
Alpha-lipoic acid reduced the plasma levels of glutamic pyruvic transaminase, blood urea nitrogen, lactate dehydrogenase, tumor necrosis factor-&agr;, nitric oxide metabolites, and thrombin-antithrombin complex, which increased markedly after LPS challenge.
The induction of inducible nitric oxide synthase both in the liver and the lung and vascular superoxide anion production were also significantly suppressed by ALA.
Shock  •  2015  |  View Paper
Concomitant use of α-lipoic acid and cyclosporine significantly increased nitric oxide production, cyclooxygenase-2 and miR-210 gene expression compared to all other studied groups.
Toxicology and applied pharmacology  •  2015  |  View Paper
As a result, we can readily suggest that ALA and PTX can have protective effects by decreasing MDA, NO , BUN and urea values as antioxidants against MTX-induced damage in liver and kidney of rats.
Environmental toxicology and pharmacology  •  2015  |  View Paper
LA treatment inhibited LPS-induced NO , TNF-α, IL-1β and IL-6 production, and enhanced IL-10 secretion, and compared with LPS stimulation alone, the differences were statistically significant (P<0.05).
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology  •  2014  |  View Paper
It was observed in LPS-treated animals that the LA prevented the increase in 1.2 fold of NO production, decreased (30-40%) mitochondrial complex I-III and IV activities, and decreased (26%) membrane potential and cardiolipin oxidation (76%).
Food & function  •  2014  |  View Paper
LA (10 and 50 μM) after 24 h of treatment significantly decreased the formation of reactive oxygen species (ROS) and nitric oxide (NO) levels, and increased glutamate uptake (up to 20%), GS activity (25%) and GSH content (up to 40%).
International Journal of Developmental Neuroscience  •  2013  |  View Paper
eNOS expression and NO level were increased after ALA intervention compared with HS group(P<0.05).
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology  •  2012  |  View Paper
The nitric oxide level was also increased by 500 microM MG treatment, but it was significantly inhibited by lipoic acid.
Journal of nutritional science and vitaminology  •  2008  |  View Paper
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