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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ Alpha-lipoic acid significantly increased glutathione level and significantly decreased MDA, NO , TNF-alpha, Fas-L, MMP-2, troponin-I levels, and TGF-beta gene expression.”
Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes.“Pre-incubation of cells with alpha-lipoic acid increases their capacity to reduce extracellular ferricyanide, to recycle intracellular dehydroascorbic acid to ascorbate, to decrease reactive oxygen species generated by redox cycling of menadione, and to generate nitric oxide.”
“ Alpha-lipoic acid reduced the plasma levels of glutamic pyruvic transaminase, blood urea nitrogen, lactate dehydrogenase, tumor necrosis factor-&agr;, nitric oxide metabolites, and thrombin-antithrombin complex, which increased markedly after LPS challenge.”
“The induction of inducible nitric oxide synthase both in the liver and the lung and vascular superoxide anion production were also significantly suppressed by ALA.”
Alpha-Lipoic Acid Prevents Endotoxic Shock and Multiple Organ Dysfunction Syndrome Induced by Endotoxemia in Rats“Concomitant use of α-lipoic acid and cyclosporine significantly increased nitric oxide production, cyclooxygenase-2 and miR-210 gene expression compared to all other studied groups.”
“As a result, we can readily suggest that ALA and PTX can have protective effects by decreasing MDA, NO , BUN and urea values as antioxidants against MTX-induced damage in liver and kidney of rats.”
“ LA treatment inhibited LPS-induced NO , TNF-α, IL-1β and IL-6 production, and enhanced IL-10 secretion, and compared with LPS stimulation alone, the differences were statistically significant (P<0.05).”
“It was observed in LPS-treated animals that the LA prevented the increase in 1.2 fold of NO production, decreased (30-40%) mitochondrial complex I-III and IV activities, and decreased (26%) membrane potential and cardiolipin oxidation (76%).”
“ LA (10 and 50 μM) after 24 h of treatment significantly decreased the formation of reactive oxygen species (ROS) and nitric oxide (NO) levels, and increased glutamate uptake (up to 20%), GS activity (25%) and GSH content (up to 40%).”
“eNOS expression and NO level were increased after ALA intervention compared with HS group(P<0.05).”
“The nitric oxide level was also increased by 500 microM MG treatment, but it was significantly inhibited by lipoic acid.”
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