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Discover Supplement-Drug Interactions

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Last Updated: a year ago

Possible Interaction: Alpha-lipoic acid and Methotrexate

Research Papers that Mention the Interaction

Conclusions: Oxidative damage of MTX in rat lung is partially reduced when combined with ALA.
Journal of investigative surgery : the official journal of the Academy of Surgical Research  •  2018  |  View Paper
On the other hand, ALA treatment reversed all these biochemical indices as well as histopathological alterations induced by MTX.
Acta cirurgica brasileira  •  2015  |  View Paper
In conclusion, it can be stated that, although ALA is more effective in preventing the toxic effects of MTX on the liver and kidney, PTX also has a preventive effect.
Environmental toxicology and pharmacology  •  2015  |  View Paper
ALA treatment reversed all biochemical indices as well as histopathological alterations induced by MTX administration.
European review for medical and pharmacological sciences  •  2015  |  View Paper
These findings suggest that co-administration of LA with MTX is associated with reduction in oxidative injury and tissue damage in the intestine.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology  •  2011  |  View Paper