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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Metformin
Research Papers that Mention the Interaction
“…,α-LA reversed the decreased activation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase, and increased the levels of peroxisome proliferator-activated receptor delta and sirtuin3 in diabetic mouse retinas, similar to results shown after metformin treatment of retinal pigment epithelial cells (RPE) exposed to high glucose.”
Alpha-lipoic acid reduces retinal cell death in diabetic mice.“Methods: In this case–control clinical study, a total number of 70 patients with T2DM compared with 30 healthy controls were divided into …: Group A (n = 30), healthy controls; Group B (n = 36), T2DM patients on metformin and Group C (n = 34), T2DM patients on metformin … TA 600 …/day.”
“sVCAM-1 level was high in patients with T2DM (3.74 ± 1.34 …, which decreased by metformin monotherapy to 2.32 ± 0.67 ng/ml or metformin … TA to 1.98 ± 0.31 ng/ml (P < 0.01), but … illustrated insignificant difference compared to metformin alone (P = 0.29).”
Impact of thioctic acid on glycemic indices and associated inflammatory-induced endothelial dysfunction in patients with type 2 diabetes mellitus: A case control study
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