“Both classical analgesics (nonsteroidal anti-…, phenytoin or carbamazepine and α-lipoic acid can modulate the balance between … drugs such as indomethacin, meloxicam , tenoxicam, valdecoxib or some metabolites of analgesic drugs formed by the activity of tissue … gastrointestinal ulcers, hepatic failure, agranulocytosis, aplastic anemia, neutropenia, opiate-induced hyperalgesia and tolerance.”