Possible Interaction: Alpha-lipoic acid and Iron, Dietary

“Conclusion By decreasing the IRP2 level and via the IRP2/IRE pathway, α-LA can increase FP1 level, promote the outflow of iron ions from cells, and reduce iron deposition in the substantia nigra of PD model rats, thereby alleviating brain injury in PD rats induced by 6-OHDA.”

“BACKGROUND The antioxidant properties of alpha-lipoic acid (ALA) are associated with its ability to reduce iron in cells and tissues, which is partly due to its inhibiting effect on iron uptake from transferrin and its promoting effect on iron deposition into ferritin.”

“In the present study we examined the in vivo effects of lipoic acid treatment on Fe metabolism in cultured lens epithelial cells, and found that LA decreases Fe uptake from transferrin, increases Fe deposition into ferritin and increases the concentration of this protein.”

“Therefore, LA may reduce the risk of Fe induced oxidative damage and also might be useful as a treatment of Fe overload.”

“Interestingly, ALA attenuated 6-OHDA-induced iron accumulation both in vivo and in vitro by antagonizing the 6-OHDA-induced upregulation of iron regulatory protein 2 and divalent metal transporter 1.”