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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Interleukin-10
Research Papers that Mention the Interaction
“Though not significant, LA appeared to have a biphasic effect on IL-10 production.”
Lipoic Acid Attenuates Inflammation via cAMP and Protein Kinase A Signaling“… R-LA stimulated the activation of PI3K-Akt through mTORC1 and …, rictor and raptor) and production of antiinflammatory cytokine, IL-10 which led to the inactivation of glycogen synthase kinase-3β (GSK-3β) and reduction …/Bcl2 and Bax/Bcl-xL ratios, accompanied by inhibition of the cleaved caspase-3.”
“The LA treatment group showed markedly up-regulated levels of the Treg cytokine IL-10 and Treg transcription factor Foxp3.”
Anti-allergic rhinitis activity of α-lipoic acid via balancing Th17/Treg expression and enhancing Nrf2/HO-1 pathway signaling“Furthermore, α-LA induced the polarization of microglia to the M2 phenotype, modulated the expression of IL-1β, IL-6, TNF-α and IL-10 , and attenuated the activation of NF-κB after MCAO.”
“Treatment with ALA significantly attenuated the levels of superoxide, gp91(phox), gp47(phox), ACE, AT1-R, IL-1β and IL-6, increased the levels of IL-10 and Cu/Zn-SOD, and decreased MAP and RSNA compared with high-salt induced hypertensive rats.”
“ LA treatment inhibited LPS-induced NO, TNF-α, IL-1β and IL-6 production, and enhanced IL-10 secretion, and compared with LPS stimulation alone, the differences were statistically significant (P<0.05).”
“Furthermore, thioctic acid increased IL‐10 mRNA expression while indomethacin decreased its expression.”
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