Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Alpha-lipoic acid and Glutathione Disulfide

Research Papers that Mention the Interaction

R-LA (12.5–50 μM) aggrandized the reduced glutathione over glutathione disulfide ratio followed by a reduction in the intracellular reactive oxygen species level and an increase in mitochondrial membrane potential following H2O2 exposure.
Drug design, development and therapy  •  2014  |  View Paper
LA significantly increased the activities of antioxidant enzymes, and reduced glutathione while decreasing the levels of oxidative glutathione and malondialdehyde in the intestinal mucosa (p < 0.05).
Journal of animal physiology and animal nutrition  •  2017  |  View Paper
LA (60 or 100 mg/kg) before LPS administration decreased the level of GSSG (p<0.05) and increased the level of GSH in spleen homogenates (p<0.05), resulting in an increase in the GSH/GSSG ratio compared with the LPS group (p<0.01).
Pharmacological reports : PR  •  2013  |  View Paper
We present evidence that, upon reaction of free lipoic acid with oxidized glutathione in solution, disulfide exchange occurs rapidly, producing oxidized lipoic acid and reduced glutathione.
Free radical biology & medicine  •  2013  |  View Paper
In addition, the treatment of LA after LPS challenge significantly decreased the level of GSSG , increased the level of GSH in heart homogenates resulting in an increase of the GSH/GSSG ratio compared with the LPS group.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society  •  2009  |  View Paper
Lipoic acid administration to aged rats reduced the levels of mitochondrial LPO, 8-oxo-dG and oxidized glutathione and enhanced reduced glutathione, ATP, lipoic acid and ETC complex activities.
Neurochemical research  •  2007  |  View Paper
Both tissues showed an increase (P < 0.05) in oxidized glutathione (GSSG) when fed ALP as compared with other treatments.
The Journal of nutritional biochemistry  •  2004  |  View Paper
In conclusion, present data … the combination of the ALA , AA6P, and FO have … the recycling of GSSG to reduced GSH in erythrocytes of diabetic rats, and in addition to this, oxidative stress was … and AA6P, and unsaturated fatty acid degree was raised by the effects of ALA and FO.
Journal of cellular biochemistry  •  2002  |  View Paper
Notably, protection against lipid peroxidation was afforded by the combination of oxidized glutathione (GSSG) and reduced lipoic acid.
Biochimica et biophysica acta  •  1988  |  View Paper