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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“ R-LA (12.5–50 μM) aggrandized the reduced glutathione over glutathione disulfide ratio followed by a reduction in the intracellular reactive oxygen species level and an increase in mitochondrial membrane potential following H2O2 exposure.”
(R)-(+)-α-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines“ LA significantly increased the activities of antioxidant enzymes, and reduced glutathione while decreasing the levels of oxidative glutathione and malondialdehyde in the intestinal mucosa (p < 0.05).”
Supplemental lipoic acid relieves post‐weaning diarrhoea by decreasing intestinal permeability in rats“ LA (60 or 100 mg/kg) before LPS administration decreased the level of GSSG (p<0.05) and increased the level of GSH in spleen homogenates (p<0.05), resulting in an increase in the GSH/GSSG ratio compared with the LPS group (p<0.01).”
“We present evidence that, upon reaction of free lipoic acid with oxidized glutathione in solution, disulfide exchange occurs rapidly, producing oxidized lipoic acid and reduced glutathione.”
“In addition, the treatment of LA after LPS challenge significantly decreased the level of GSSG , increased the level of GSH in heart homogenates resulting in an increase of the GSH/GSSG ratio compared with the LPS group.”
“ Lipoic acid administration to aged rats reduced the levels of mitochondrial LPO, 8-oxo-dG and oxidized glutathione and enhanced reduced glutathione, ATP, lipoic acid and ETC complex activities.”
“Both tissues showed an increase (P < 0.05) in oxidized glutathione (GSSG) when fed ALP as compared with other treatments.”
“In conclusion, present data … the combination of the ALA , AA6P, and FO have … the recycling of GSSG to reduced GSH in erythrocytes of diabetic rats, and in addition to this, oxidative stress was … and AA6P, and unsaturated fatty acid degree was raised by the effects of ALA and FO.”
“Notably, protection against lipid peroxidation was afforded by the combination of oxidized glutathione (GSSG) and reduced lipoic acid.”
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