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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Alpha-lipoic acid
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Furthermore, we found that LA not only inhibited the activity of calpain1, which has been associated with tauopathy development and neurodegeneration via modulating the activity of several kinases, but also significantly decreased the calcium content of brain tissue in LA-treated mice.”
α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice“ Calcium enhances the rate of glutathionylation by increasing the half-life of reduced lipoic acid during enzyme catalysis.”
“These results indicate that, under certain conditions, LA stimulates Ca2+ -induced MPT through the decrease in loading capacity of Ca2+ and that MPT is involved in LA-induced apoptotic cell death.”
“Regarding the mechanism of action, thioctic acid firstly reverses the effect of 6 mM calcium in the superfusion fluid and secondly reverses the effect of apamin, an highly selective neurotoxin of bee venom, acting as the most specific blocker of the small conductance calcium dependent potassium channel.”
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