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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
Research Papers that Mention the Interaction
“Furthermore, the GSH-increasing agents N-acetylcysteine and lipoic acid significantly inhibited the combined cytotoxicity of As2O3 and BSO.”
Enhancement of arsenic trioxide-induced apoptosis in renal cell carcinoma cells by L-buthionine sulfoximine.“When cells were stressed by BSO, LA diminished cell death and decreased GSH/GSSG ratio.”
Neuroprotection of Brain Cells by Lipoic Acid Treatment after Cellular Stress.“Treatment with l-buthionine-sulfoximine , an inhibitor of intracellular glutathione biosynthesis, completely abolished the protective effects of LA on dRib-mediated glutathione depletion and cytotoxicity in HIT-T15 cells.”
“However, RS-alpha-lipoic acid , RS-alpha-dihydrolipoic acid, and S-alpha-lipoic acid failed to protect cells against the degeneration induced by prolonged exposure to BSO , whereas the natural form, R-alpha-lipoic, was partially active under the same conditions.”
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