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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“ ALA reduced ADMA while no change was observed with placebo (mean change -0.05 micromol/1[95% CI: -0.01; -0.09] vs. 0.01 micromol/1 [95% CI: -0.05; -0.03]; ANOVA p = 0.031).”
Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus.“ ALA significantly decreased ADMA level in culture media of endothelial cells.”
“These results suggest that ALA reduces ADMA level by enhancing DDAH activity and DDAH II gene expression, thus providing a novel mechanism by which ALA regulates endothelial function.”
Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells.“Conclusion Considering that ADMA is produced by oxidative stress in MS patients and leads to increase of inflammation, ALA may have the potential of beneficial effects in them, in part, by decreasing the plasma level of ADMA and stopping progression.”
Effect of alpha-lipoic acid on asymmetric dimethylarginine and disability in multiple sclerosis patients: A randomized clinical trial
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