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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Alpha-lipoic acid and Asymmetric Dimethylarginine

Research Papers that Mention the Interaction

ALA reduced ADMA while no change was observed with placebo (mean change -0.05 micromol/1[95% CI: -0.01; -0.09] vs. 0.01 micromol/1 [95% CI: -0.05; -0.03]; ANOVA p = 0.031).
Translational research : the journal of laboratory and clinical medicine  •  2010  |  View Paper
ALA significantly decreased ADMA level in culture media of endothelial cells.
These results suggest that ALA reduces ADMA level by enhancing DDAH activity and DDAH II gene expression, thus providing a novel mechanism by which ALA regulates endothelial function.
Biochemical and biophysical research communications  •  2010  |  View Paper
Conclusion Considering that ADMA is produced by oxidative stress in MS patients and leads to increase of inflammation, ALA may have the potential of beneficial effects in them, in part, by decreasing the plasma level of ADMA and stopping progression.
Electronic physician  •  2017  |  View Paper