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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-lipoic acid
drug:
Arsenic Trioxide
Research Papers that Mention the Interaction
“ alpha-Lipoic acid ameliorated arsenic trioxide-induced cytotoxicity and reduced superoxide anion production in HEK293 cells, whereas it had no effect in promyelocytic leukemia cells (HL-60 cells and NB4 cells) and myeloma cells (KMS12BM cells and U266 cells).”
An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide.“Furthermore, the GSH-increasing agents N-acetylcysteine and lipoic acid significantly inhibited the combined cytotoxicity of As2O3 and BSO.”
“On the other hand, even when BAL or TA were added directly into thip loop containing As2O3 , the content of As2O3 absorbed in blood decreased markedly, compared with that of the control group.”
[Metabolism of arsenic (15). Influence of arsenic antidotes on intestinal absorption of arsenic trioxide].
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