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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-Ketoglutaric Acid
drug:
Sodium Thiosulfate
Research Papers that Mention the Interaction
“A single dose of alpha-ketoglutaric acid (500 mg/kg) and sodium thiosulfate (1000 mg/kg) solutions afforded a 70% increase in survivability of the exposed animals.”
“ Alpha-ketoglutaric acid and sodium thiosulfate antagonize the toxic effects of cyanide.”
“However, when these doses of alpha-ketoglutaric acid and sodium thiosulfate were combined, protection was increased by 18%.”
Antidotal efficacy of alpha-ketoglutaric acid and sodium thiosulfate in cyanide poisoning.“It is apparent from these studies that the administration of alpha-ketoglutaric acid in conjunction with sodium thiosulfate resulted in fewer animal deaths than sodium nitrite and sodium thiosulfate without the dangerous formation of methemoglobin.”
“The combination of alpha-ketoglutaric acid and sodium thiosulfate increased the LD50 value of cyanide to 101 mg/kg.”
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