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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Alpha-Ketoglutaric Acid and Sodium Thiosulfate

Research Papers that Mention the Interaction

A single dose of alpha-ketoglutaric acid (500 mg/kg) and sodium thiosulfate (1000 mg/kg) solutions afforded a 70% increase in survivability of the exposed animals.
Alpha-ketoglutaric acid and sodium thiosulfate antagonize the toxic effects of cyanide.
However, when these doses of alpha-ketoglutaric acid and sodium thiosulfate were combined, protection was increased by 18%.
Journal of toxicology. Clinical toxicology  •  1995  |  View Paper
It is apparent from these studies that the administration of alpha-ketoglutaric acid in conjunction with sodium thiosulfate resulted in fewer animal deaths than sodium nitrite and sodium thiosulfate without the dangerous formation of methemoglobin.
The combination of alpha-ketoglutaric acid and sodium thiosulfate increased the LD50 value of cyanide to 101 mg/kg.
Toxicology and applied pharmacology  •  1986  |  View Paper