Possible Interaction: Alpha-Ketoglutaric Acid and Aspartate

“The presence of α-ketoglutarate in the preliminary incubation mixture decreased inhibition while aspartate accentuated it.”

“Addition of malate, aspartate, α-ketoglutarate, and glutamate did not increase the utilization of uniformly labeled l-lactate-14C by tissue of fasted rats, but aspartate and α-ketoglutarate when added together stimulated l-lactate uptake, and incorporation of 14C into CO2 and lipids.”

“Excess α-ketoglutarate (greater than 0.5 m m ) inhibits the production of ammonia from alanine and aspartate.”

“An increase in the maximum activity accompanied the decrease in the S 0.5 values for α-ketoglutarate and NADH with the addition of L-aspartate , and the kinetic response for α-ketoglutarate changed completely to a typical Michaelis-Menten type in the presence of 10 mM L-aspartate.”

“Bundle sheath strands from all three species decarboxylated aspartate with severalfold stimulation by the addition of either α-ketoglutarate (10 m m ) or pyruvate (1 m m ), with the lowest rate in D. sanguinalis.”