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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-Ketoglutaric Acid
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“Our data suggest that mitochondrial adaptation to DKG elevates the ratio of succinate or fumarate to α-KG , which in turn stabilizes HIF-1α and reprograms breast cancer cells into a stem-like state.”
HIF-1-alpha links mitochondrial perturbation to the dynamic acquisition of breast cancer tumorigenicity“This mechanism could be the reductive amination of ketoglutaric acid to form glutamate with the concomitant removal of significant amounts of ketoglutarate , preventing Krebs cycle regeneration.”
“The pathways competing with the biosynthesis of α-KG were blocked by knocking out aceA (encoding isocitrate lyase, ICL), gdh (encoding glutamate dehydrogenase, l-gluDH), and gltB (encoding glutamate synthase or glutamate-2-oxoglutarate aminotransferase, GOGAT).”
Disruption of genes for the enhanced biosynthesis of α-ketoglutarate in Corynebacterium glutamicum.
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