Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Alpha-Ketoglutaric Acid and Alpha-Ketoglutarate

Research Papers that Mention the Interaction

Our data suggest that mitochondrial adaptation to DKG elevates the ratio of succinate or fumarate to α-KG , which in turn stabilizes HIF-1α and reprograms breast cancer cells into a stem-like state.
Oncotarget  •  2016  |  View Paper
This mechanism could be the reductive amination of ketoglutaric acid to form glutamate with the concomitant removal of significant amounts of ketoglutarate , preventing Krebs cycle regeneration.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1954  |  View Paper
The pathways competing with the biosynthesis of α-KG were blocked by knocking out aceA (encoding isocitrate lyase, ICL), gdh (encoding glutamate dehydrogenase, l-gluDH), and gltB (encoding glutamate synthase or glutamate-2-oxoglutarate aminotransferase, GOGAT).
Canadian journal of microbiology  •  2012  |  View Paper