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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-Aminobutyric Acid
drug:
Deoxycholate
Research Papers that Mention the Interaction
“In contrast to prior in vitro studies, DCA alone at this concentration did not affect LI, but when combined with NaBu, DCA inhibited the effects of NaBu at the crypt base and surface.”
“The conclusions are: (1) the in vivo proliferative effects of NaBu are selective to the crypt base, (… level does not promote crypt surface hyperproliferation but does inhibit butyrate's proliferative effect, and (3) NaBu … DCA interact in a complex and antagonistic manner … proliferation, in the rat colon, in vivo.”
“We hypothesized that NaBu and DCA have similar selective and antagonistic effects on the colonic crypt proliferative pattern, in vivo.”
Deoxycholate inhibits in vivo butyrate-mediated BrDU labeling of the colonic crypt.
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