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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alpha-Aminobutyric Acid
drug:
Aldesleukin
Research Papers that Mention the Interaction
“ NaBu dose dependently increased the acetylation levels of histone H4 at concentrations which effectively enhanced anti-trinitrophenyl (TNP) antibody production in the presence of IL-2.”
“These results suggest that the NaBu-induced enhancement of anti-TNP antibody production in the …-2 is mediated through a moderate increase in the level of histone acetylation and that NaBu has both stimulating and inhibiting activities for anti-… production, the latter of which is overcome by IL-2.”
An increase in histone acetylation and IL-2 antagonizing the immunoinhibitory effect are necessary for augmentation by butyrate of in vitro anti-TNP antibody production.“The full enhancing effect of NaBu was also detected when IL-2 was added to the B cell cultures, while IL-2 alone had no stimulatory effect on the control PFC response.”
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