“ DAS at 25–100 μM decreased the viability of Ca Ski cells by increasing G0/G1 phase arrest followed by induction of apoptosis in concentration- and time-dependent effects.”
“Flow cytomteric assay indicated that DAS (75 μM) promoted the production of Ca2+ accumulation and decreased the level of mitochondrial membrane potential in Ca Ski cells.”
“Furthermore, DAS induced mitochondrial dysfunction, leading to the release of cytochrome c for causing apoptosis in Ca Ski cells.”
“The characteristics of apoptosis, such as morphological changes and DNA condensation, altered the ratio of Bax/Bcl-2 and sub-G1 phase occurred in Ca Ski cells after exposure to DAS.”