supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Allopurinol
supplement:
Vitamin E
Research Papers that Mention the Interaction
“Although, there was a significant decrease in … values of apoptosis in animals receiving vitamine E (8.7%–….3%) and allopurinol (18.4%–13.5%) (P<0.05), animals on verapamil, MgOH and potassium citrate medication … an increase in these values or the change was not found to be significant.”
Limitation of apoptotic changes in renal tubular cell injury induced by hyperoxaluria“As allopurinol , a xanthine oxidase inhibitor, prevents the decrease in alpha-tocopherol , xanthine oxidase may contribute to this oxidative stress.”
“Conclusions Allopurinol synergistically increases the protective effect of metformin and vitamin E in treatment of NAFLD, namely via reduction of uric acid synthesis and iNOS expression.”
“Results Combination of allopurinol plus metformin plus vitamin E significantly attenuated fatty changes compared to their respective monotherapy.”
Allopurinol potentiates the hepatoprotective effect of metformin and vitamin E in fructose-induced fatty liver in rats
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback