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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Allopurinol
supplement:
Vitamin C
Research Papers that Mention the Interaction
“One trial including 40 participants, at moderate to high risk of bias, compared vitamin C alone with allopurinol and with allopurinol plus vitamin C in a three-arm trial.”
Dietary supplements for chronic gout.“The reduction in SU level over 8 … was significantly less in those patients receiving vitamin C compared to those who started or increased the dose of allopurinol (mean reduction 0.014 mmoles/liter [0.23 mg/dl] versus 0.118 mmoles/liter [1.9 mg/dl]; P < 0.001).”
“The binding reaction was not inhibited by superoxide dismutase or allopurinol , but was strongly inhibited by ascorbic acid and glutathione.”
Methyldopa binding to cells in culture.
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