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Last Updated: 2 years ago

Possible Interaction: Allopurinol and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

Metabolic dysfunction of tryptophan was also proven to be induced by allopurinol in case of Kunming mice with hyperuricemia.
Molecular bioSystems  •  2012  |  View Paper
The l-tryptophan induced increases in brain concentrations of 5-HT and 5-hydroxyindoleacetic acid were more pronounced after pretreatment with allopurinol.
Psychopharmacologia  •  2004  |  View Paper
The analgesic effects of tryptophan are potentiated by allopurinol (CAS 315-30-0).
The combined allopurinol and tryptophan treatment elevates the serotonin levels furtherly when they are compared with the values observed in animals receiving tryptophan only.
Arzneimittel-Forschung  •  1991  |  View Paper
Allopurinol , an inhibitor of hepatic tryptophan pyrrolase activity, prevented the reduction in the indole levels induced by 5‐ALA.
Journal of neuroscience research  •  1989  |  View Paper
The activity of liver tryptophan pyrrolase was reduced by 60% 3 h after the injection of allopurinol (20 mg kg-l).
The Journal of pharmacy and pharmacology  •  1974  |  View Paper
Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) selectively inhibits the apotryptophan pyrrolase activity in homogenates of rat liver in vitro and after intraperitoneal administration.
It is suggested that allopurinol inhibits rat liver tryptophan pyrrolase activity in vitro and after administration by preventing the conjugation of the apoenzyme with its haem activator.
Pretreatment of rats with allopurinol completely prevents the enhancement of the pyrrolase activities by tryptophan , salicylate or ethanol.
The Biochemical journal  •  1973  |  View Paper
Allopurinol given simultaneously with tryptophan strongly depresssed tryptophan oxygenase activity yet did not decrease the rise in NAD.
Biochimica et biophysica acta  •  1971  |  View Paper