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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Allopurinol
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Metabolic dysfunction of tryptophan was also proven to be induced by allopurinol in case of Kunming mice with hyperuricemia.”
Metabolite target analysis of human urine combined with pattern recognition techniques for the study of symptomatic gout.“The l-tryptophan induced increases in brain concentrations of 5-HT and 5-hydroxyindoleacetic acid were more pronounced after pretreatment with allopurinol.”
Effects of l-tryptophan on motor activity in mice“The analgesic effects of tryptophan are potentiated by allopurinol (CAS 315-30-0).”
“The combined allopurinol and tryptophan treatment elevates the serotonin levels furtherly when they are compared with the values observed in animals receiving tryptophan only.”
“ Allopurinol , an inhibitor of hepatic tryptophan pyrrolase activity, prevented the reduction in the indole levels induced by 5‐ALA.”
“The activity of liver tryptophan pyrrolase was reduced by 60% 3 h after the injection of allopurinol (20 mg kg-l).”
“ Allopurinol (4-hydroxypyrazolo[3,4-d]pyrimidine) selectively inhibits the apotryptophan pyrrolase activity in homogenates of rat liver in vitro and after intraperitoneal administration.”
“It is suggested that allopurinol inhibits rat liver tryptophan pyrrolase activity in vitro and after administration by preventing the conjugation of the apoenzyme with its haem activator.”
“Pretreatment of rats with allopurinol completely prevents the enhancement of the pyrrolase activities by tryptophan , salicylate or ethanol.”
“ Allopurinol given simultaneously with tryptophan strongly depresssed tryptophan oxygenase activity yet did not decrease the rise in NAD.”
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