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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Allopurinol
supplement:
Thiamine Pyrophosphate
Research Papers that Mention the Interaction
“This is consistent with the … that the intracellular concentrations of TPP and TPPR-MP are sufficient … inhibit the conversion of allopurinol to allopurinol ribonucleotide (HPPR-MP) by the hypoxanthine-guanine phosphoribosyltransferase by 30 per cent and the amination of HPPR-MP by adenylosuccinate synthetase by 50 per cent respectively.”
Antileishmanial action of 4-thiopyrazolo (3.4-d) pyrimidine and its ribonucleoside. Biological effects and metabolism.
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