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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Allopurinol
supplement:
NADH
Research Papers that Mention the Interaction
“Superoxide production is potentiated in the presence of NADH and inhibited by allopurinol.”
Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells“Moreover, the molybdenum center inhibitor allopurinol inhibits the PR5-sustained oxidation of xanthine and NADH equally well, whereas the flavin adenine dinucleotide site inhibitor diphenyliodonium (DPI) markedly inhibits only the PR5-sustained oxidation of NADH.”
“The reduction of guanoxabenz required xanthine or NADH as reducing substrates, while the process could be blocked by allopurinol , a selective inhibitor of xanthine oxidase.”
“The N-reduction required NADH or hypoxanthine or xanthine and was strongly inhibited by allopurinol.”
“ Allopurinol also inhibits the activation of the enzyme in vitro by ascorbate, ethanol plus NAD(+), NADH , hypoxanthine or xanthine.”
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