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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Allopurinol
supplement:
Inosine
Research Papers that Mention the Interaction
“ Allopurinol increased plasma concentration of hypoxanthine, xanthine and inosine 4, 10 and 3 times, respectively, in relation to baseline values.”
[Purine transport through the blood-brain barrier in hypoxanthine phosphoribosyltransferase deficiency].“ Allopurinol inhibits purine degradation under severe hypoxic conditions and results in a significant increase in brain tissue levels of adenosine and inosine.”
Effect of allopurinol on brain adenosine levels during hypoxia in newborn piglets“With allopurinol , guanosine (0.1 and 0.15 mM) and inosine (0.1‐1.0 mM) gave significantly higher (P < 0.01) total serosal purine concentrations than their respective bases.”
“It was revealed that allopurinol enhances the synthesis of adenine nucleotides from administered inosine in the brain and liver of rats.”
“However when allopurinol is combined with the above two compounds in addition to inosine , alpha-ketoglutarate and oxalacetate 48 hr survival was increased to 43%.”
“Allantoic acid production by the nodule cytosol fraction with inosine-5'-monophosphate, inosine , xanthosine-5'-monophosphate, xanthosine, hypoxanthine, or xanthine as substrates was NAD(+)-dependent and blocked by allopurinol.”
Allantoic Acid Synthesis in Soybean Root Nodule Cytosol via Xanthine Dehydrogenase.
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