Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Allopurinol and Inosine



Research Papers that Mention the Interaction

Allopurinol increased plasma concentration of hypoxanthine, xanthine and inosine 4, 10 and 3 times, respectively, in relation to baseline values.
Medicina clinica  •  1989  |  View Paper
Allopurinol inhibits purine degradation under severe hypoxic conditions and results in a significant increase in brain tissue levels of adenosine and inosine.
Brain Research  •  2006  |  View Paper
With allopurinol , guanosine (0.1 and 0.15 mM) and inosine (0.1‐1.0 mM) gave significantly higher (P < 0.01) total serosal purine concentrations than their respective bases.
The Journal of physiology  •  1993  |  View Paper
It was revealed that allopurinol enhances the synthesis of adenine nucleotides from administered inosine in the brain and liver of rats.
Ceskoslovenska neurologie a neurochirurgie  •  1989  |  View Paper
However when allopurinol is combined with the above two compounds in addition to inosine , alpha-ketoglutarate and oxalacetate 48 hr survival was increased to 43%.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1972  |  View Paper
Allantoic acid production by the nodule cytosol fraction with inosine-5'-monophosphate, inosine , xanthosine-5'-monophosphate, xanthosine, hypoxanthine, or xanthine as substrates was NAD(+)-dependent and blocked by allopurinol.
Plant physiology  •  1980  |  View Paper